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Order NO. D624518
人CEP57抗原（重組蛋白）
| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D624518-0001 | 1 MG | 預計30日內發貨 |
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| D624518-0050 | 50 UG | 預計30日內發貨 |
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| D624518-0100 | 100 UG | 預計30日內發貨 |
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產品描述
概述
Fusion protein corresponding to a region derived from 1-270 amino acids of human CEP57
屬性
| Full name: | centrosomal protein 57 |
| Synonyms: | MVA2; PIG8; TSP57 |
| Swissprot: | Q86XR8-3 |
| Gene Accession: | BC039711 |
| Gene ID: | 9702 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Research areas: | Signal Transduction, Stem Cells |
| Reconstitution: | Reconstitute with sterile distilled water or deionized water to 1 mg/ml |
| Background: | This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (The background information is obtained from official databases and does not represent the product information.) |
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