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| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D225968-0025 | 25 ul | 現貨 |
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| D225968-0100 | 100 ul | 現貨 |
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| D225968-0200 | 200 ul | 現貨 |
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概述
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
應用
酶聯免疫吸附測定（ELISA），免疫印跡（WB），免疫組織化學（IHC）
屬性
| 保存緩衝液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 運輸條件 | 2-8°C |
| 靶點 Uniprot 登記號 | Q96C10 |
| 靶點基因 ID | 79132 |
| 靶點全稱 | DExH-box helicase 58 |
| 靶點別名 | LGP2; RLR-3; D11LGP2; D11lgp2e |
| 靶點研究領域 | Epigenetics and Nuclear Signaling, Immunology |
| 亞型 | Immunogen-specific rabbit IgG |
