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| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D224518-0025 | 25 ul | 現貨 |
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| D224518-0100 | 100 ul | 現貨 |
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| D224518-0200 | 200 ul | 現貨 |
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概述
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
應用
酶聯免疫吸附測定（ELISA），免疫印跡（WB），免疫組織化學（IHC）
屬性
| 保存緩衝液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 運輸條件 | 2-8°C |
| 靶點 Uniprot 登記號 | Q86XR8 |
| 靶點基因 ID | 9702 |
| 靶點全稱 | centrosomal protein 57 |
| 靶點別名 | MVA2; PIG8; TSP57 |
| 靶點研究領域 | Signal Transduction, Stem Cells |
| 亞型 | Immunogen-specific rabbit IgG |
