Order NO. D224166
產品描述
概述
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
應用
酶聯免疫吸附測定(ELISA),免疫組織化學(IHC)
屬性
保存緩衝液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
運輸條件 |
2-8°C
|
靶點 Uniprot 登記號 |
O14795
|
靶點基因 ID |
10497
|
靶點全稱 |
unc-13 homolog B
|
靶點別名 |
UNC13; MUNC13; Unc13h2; munc13-2
|
靶點研究領域 |
Signal Transduction, Neuroscience
|
亞型 |
Immunogen-specific rabbit IgG
|