Order NO. D223045
產品描述
概述
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
應用
酶聯免疫吸附測定(ELISA),免疫組織化學(IHC)
屬性
保存緩衝液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
運輸條件 |
2-8°C
|
靶點 Uniprot 登記號 |
Q8TEB7
|
靶點基因 ID |
79589
|
靶點全稱 |
ring finger protein 128
|
靶點別名 |
GRAIL
|
靶點研究領域 |
Cell Biology
|
亞型 |
Immunogen-specific rabbit IgG
|