Order NO. D199442
產品描述
概述
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
應用
免疫印跡（WB），免疫組織化學（IHC），免疫熒光（IF），流式細胞術（FCM）
屬性
| 保存緩衝液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 運輸條件 |
2-8°C
|
| 靶點 Uniprot 登記號 |
P04637
|
| 靶點基因 ID |
7157
|
| 靶點全稱 |
tumor protein p53
|
| 靶點別名 |
P53; BCC7; LFS1; BMFS5; TRP53
|
| 靶點研究領域 |
Cell Biology, Epigenetics and Nuclear Signaling, Cancer
|
| 亞型 |
IgG1
|
