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| 編 號 | 規格 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D162786-0025 | 25 ul | 現貨 | 待詢價 | 待詢價 | |
| D162786-0100 | 100 ul | 現貨 | 待詢價 | 待詢價 | |
| D162786-0200 | 200 ul | 現貨 | 待詢價 | 待詢價 |
概述
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
應用
酶聯免疫吸附測定（ELISA），免疫組織化學（IHC）
屬性
| 保存緩衝液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 運輸條件 | 2-8°C |
| 靶點 Uniprot 登記號 | Q9H2X3 |
| 靶點基因 ID | 10332 |
| 靶點全稱 | C-type lectin domain family 4, member M |
| 靶點別名 | CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR |
| 靶點研究領域 | Cardiovascular, Immunology |
| 亞型 | Immunogen-specific rabbit IgG |
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