概述

Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Zinc finger and SCAN domain-containing protein 16 (ZSCAN16), also known as ZNF392 or ZNF435, is a 348 amino acid member of the Krüppel C2H2-type zinc finger protein family. Localized to the nucleus, ZSCAN16 contains four C2H2-type zinc fingers at the carboxy terminus and one SCAN box domain, a leucine rich region of about 80 amino acids, at the amino terminus through which it is thought to be involved in DNA-binding and transcriptional regulation. ZSCAN16 has been shown to repress reporter gene transcription, and overexpression of ZNF435 also suppressed the transcriptional activities of AP-1μ. Because AP-1μ is activated by MAPK-mediated phosphorylation, ZNF435 is though to be involved in the MAPK pathway.

應用

免疫印跡（WB）

屬性